New research identifies SAMe in human breast milk

May 31, 2023

“It is tempting to hypothesize that SAMe may be a crucial nutrient in infant growth and development and may play an essential role during early life”

New research identifies SAMe in human breast milk

Gnosis by Lesaffre (Gnosis) announced that Nutrients recently published a new metabolomics analysis investigating the presence of S-adenosylmethionine (SAMe) in human breast milk. In addition to using a new study method, which uncovered considerable concentrations, it adds to the evidence that SAMe supplementation may continue to be an effective option for nursing mothers.

Healthy human breast milk is known to meet the enormous requirements of a rapidly growing infant, and previous research has confirmed that metabolites of the one-carbon metabolic pool are crucial for infant development. The analysis is based on the new metabolomics approach, which investigates chemical processes involving metabolites and includes all metabolites in a cell, tissue, organ or organism with a molecular mass of less than 5,000 Daltons.

The study compared different biofluids (breast milk, maternal blood plasma, cord blood plasma, adult blood plasma and cerebrospinal fluid). The analysis showed that maternal and adult plasma SAMe levels are not significantly different, suggesting that the high SAMe content observed in breast milk derives from breast tissue and not from circulating plasma. In the analysis, the authors found a striking 44-fold increase in SAMe concentrations in breast milk compared to maternal plasma and a 12-fold increase compared to cerebrospinal fluid (CSF).

SAMe is the major methyl group donor in metabolic pathways, the researchers explain, and as such may be a necessary nutrient for proper growth and development in children. SAMe is required for most transmethylation reactions such as the biosynthesis of phosphatidylcholine, polyamine, and carnitine, as well as DNA and protein methylation. Phosphatidylcholine, for example, is an important metabolite in breast milk for neurodevelopment.

The researchers, including metabolomics expert Teodoro Bottiglieri, head of the Metabolomics Center (Dallas, TX), strongly state that given its high concentration in breast milk, it is tempting to hypothesize that SAMe may be a crucial nutrient in the growth and development of the newborn and can play an essential role during the early stages of life.

Although more studies are needed to determine the effect of consistent SAMe supplementation, the results of this study are notable in that nursing mothers can use oral SAMe supplementation to reduce the risk of post-onset depression. partum, as research indicates it may improve serotonin and dopamine receptor site binding.

Furthermore, the authors conclude, the study suggests the need to further investigate the role of SAMe in breast milk and opens opportunities to discuss a review of infant formula compositions.

This study is unique to SAMe, and its findings can be an amazing way to develop safe and effective supplements for pregnant and lactating women, says Lorena Carboni, Product Manager of Adonat Premium SAMe at Gnosis di Lesaffre. As a leading manufacturer of this nutritional ingredient known as Adonat, we seek to promote and explain its vast portfolio of science to help consumers and producers discover all its benefits and fields of application.

Adonat Premium SAMe has been a star in our portfolio of active ingredients for decades

He added: “The study of metabolomics may indeed represent a new way of understanding how this substance is used by our bodies and suggests that there is still much to discover.

SAMe was identified for the first time in 1952 by Giulio Cantoni and the studies conducted over the last fifty years have unequivocally established the key role of SAMe in cellular metabolism and in the functions of all living organisms. This natural methyl donor is involved in more than 100 biochemical pathways and its supplementation is widely suggested to benefit mood and brain function, liver and joint health.

Adonat Premium SAMe has been a star in our portfolio of active ingredients for decades, explained Marc Philouze, general manager of Gnosis by Lesaffre. We have pioneered its use in the market with some of the best global brands using our superior clinically validated superstar. It’s gratifying to see a new way to evaluate its benefits and impact on human health, particularly if that work confirms the potential it has for new mothers.

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Adonat Premium SAMe is manufactured under pharmaceutical cGMP and provides the highest content of biologically active SAMe (75%) which exceeds the USP Dietary Supplement Monograph requirement by at least 60%.


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